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KMID : 1234420100380030315
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 3 p.315 ~ p.321
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Chemical Composition and Antifungal Activity of Plant Essential Oils against Malassezia furfur
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Lee Jeong-Hyun
Lee Jae-Sug
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Abstract
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Malassezia furfur is an important causal factor for seborrheic dermatitis. Nowadays, the drugs available to treat this fungal infection are few. Several studies have documented the biological activity of essential oils. However, its antifungal properties are not completely understood, especially its anti-Malassezia activity. The aim of this study were to evaluate the effect of the plant essential oils on the growth of M. furfur using disk diffusion method and analyze by Gas chromatography-mass spectrometry (GC-MS) most active essential oils. In first screening, the 17 plant essential oils have possesses inhibitory activity against M. furfur at 2 mg/mL. Among the plant essential oils, oil of Citrus auranifoli was most active against M. furfur and its activity showed dose dependency. This anti-malassezial activity was high than that of itraconazole at 2 mg/mL. Oil of Citrus auranifolia also was phytochemically examined by GC-MS analysis, its main constituents were identified as limonene, γ-terpinene and terpinolene. It can be concluded that essential oils of Citrus auranifolia may have interesting applications to control fungal-derived diseases.
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KEYWORD
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Malassezia furfur, anti-Malassezia activity, Citrus auranifolia, essential oil, GC-MS analysi
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